HIGH IRF8 EXPRESSION CORRELATES WITH CD8 T CELL INFILTRATION AND IS A PREDICTIVE BIOMARKER OF THERAPY RESPONSE IN ER-NEGATIVE BREAST CANCER

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

Abstract Background Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2, and Ki67 has been useful as a predictive and therapeutic tool.Also, assessment of tumor-infiltrating lymphocytes has been proposed as an important prognostic aspect to be considered in certain BC subtypes.However, there

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A rare and unusual case of cycle pedal in the orbit

A 58-year-old male presented with injury in the left eye by falling over caruso milk thistle a cycle pedal.On presentation to the casualty, the cycle pedal was found penetrating onto the superomedial aspect of the left orbit.The cycle pedal was removed in toto, and computed tomography brain with orbital cuts revealed fracture in the orbital floor,

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Reimagining Research Courses for Scholar Practitioners

This essay shares the ongoing efforts of faculty in one EdD program to embrace applied research methodologies and the shifts made in research coursework to support our doctoral candidates as they explore problems of practice.Framed by third space theory, our 30x24x24 wall cabinet redesign work is positioned as the lived experience through which we

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Cholesterol suppresses antimicrobial effect of statins

Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes.On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the

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